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Unrestrained energy, full performance capacity, slow aging – who wouldn’t want their own body to feel as vital throughout their life as that of a child running light-footed across the summer meadow while playing soccer?? The latest studies and therapies could make everyone happy who wants to experience this feeling again on a regular basis. We are talking about the NAD+ molecule.
A new way to more energy, performance and youthful vitality?
Until now, we have known that if you want more energy, you should start where it comes from: in the cells. More precisely in the mitochondria. They are responsible for energy production and also ensure that anti-aging processes and detoxification processes function properly.
the mitochondria regulate everything that keeps us young and fit.
A powerful molecule that plays an incredibly important role in this context is NAD+. It is something like a fuel, with which the mitochondria function properly.
If you don’t have enough NAD+ in your body, it will make you feel low, prevent toxins from being broken down, prevent DNA damage from being repaired, and ultimately lead to unwanted diseases. 1 NAD + biosynthesis, aging, and disease.
The good news: You can increase NAD+ naturally or bring it back to optimum in a very short time with special hacks.
But beware: some of these hacks are not for everyone and some are very unconventional!
NAD+ brain reboot infusion in london
I traveled to london some time ago to get a NAD+ infusion for more energy, focus and detoxification. An interesting thing! I have documented everything in this video.
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What exactly is NAD+?
NAD+ or "nicotinamide adenine dinucleotide" is a coenzyme that is found in every living cell. Coenzymes are like little helpers that are necessary for the correct work of enzymes in the body. Without coenzymes like NAD+, many metabolic processes would not be able to run properly.
When your cell has all the enzymes, proteins and other helpers it needs for a smooth metabolism, you feel healthy and full of energy. If they are missing, on the other hand, you are depressed and listless.
NAD+ is especially important. When there are a lot of NAD+ molecules in the cell, the body can work at full speed, because there are enough helpers to assist in the work.
Effects of too little NAD+ in the body
So it should be clear that too little NAD+ is not particularly good for us. You will find out in detail what effects a low NAD+ mirror has in the next lines.
1. Less NAD+ = faster aging
While energy metabolism is still functioning properly in adolescents, progressive DNA damage leads to less NAD+. This will ultimately lead to poorer mitochondrial function through various mechanisms. 3 NAD+ and sirtuins in aging and disease.
The consequences are less energy, a worse detoxification and in the long run a disturbed cell function.
That’s why you should take a close look at the techniques for increasing NAD+ in this article if you want to live a healthy and energetic life for a long time.
2. Low NAD+ causes exhaustion
If you are feeling low, unable to perform physically or concentrate for long periods of time, it may be a sign of low NAD+ levels.
The problem: NAD+ is an important helper in the so-called redox reactions in the cell. They are essential for energy metabolism. For this reason, it is important to have sufficient NAD+. Otherwise, the cell cannot properly convert the energy from food into usable energy for the body.
Now, if you have enough NAD+ in your cells, you will automatically feel good and full of energy. All the processes in the body also run better, so you stay healthy and fit.
3. Low NAD+ levels can lead to obesity
Various enzymes of the sirtuin group ensures that important genes are switched on that optimize metabolism, accelerate fat burning and lower "bad" LDL cholesterol.
NAD+ is a critical factor that activates sirtuins. 4 NAD+ and sirtuins in aging and disease.
4. Low NAD+ levels increase the risk of sunburn and skin cancer
NAD+ minimizes skin damage from the sun and protects against sunburn and skin cancer. This is caused by absorbing the UV rays of the sun. 5 role of nicotinamide in genomic stability and skin cancer chemoprevention.
Exciting is the effect of a high NAD+ value in the body. You will notice an immense difference when you "recharge" in the sun. You feel energetic and vital afterwards, while this effect is marginal with a low level of NAD+ in the body.
Biohack for more energy: go out in the morning with your feet as bare as possible and get charged up by the first rays of the sun. So you ground yourself and give your body the sign that the day is beginning through natural light.
This is not esoteric, but will have a decisive influence on your biorhythm and hormone balance.
5. Low NAD+ can suffocate cells (hypoxia)
When there is a lack of oxygen, also called hypoxia, mitochondria do not function as they should and for good reason.
For mitochondria to work properly, oxygen is very important. If it is present only in small quantities, the mitochondria will limit their work.
Low oxygen also results in less NAD+ being produced within the cells. By the way, low NAD+ has the same effects as a lack of oxygen, even if there is enough oxygen. This is called "pseudohypoxia".
A short-term oxygen deficiency, as is the case with altitude training, by the way, it can increase your performance as the body adapts and improves the utilization of oxygen. Read more in our article about strengthening mitochondria.
This is why you should pay attention to your NAD+ level
1. NAD+ supports your brain function
If you optimize your mitochondria and thus provide more energy, this will almost always have a positive effect on your brain.
The reason for this is the immensely high energy consumption of the brain, which makes high mitochondrial density and function in neurons imperative. If these mitochondria are no longer functioning properly or there are not enough of them, brain function suffers as a result.
The importance of NAD+ for dopamine
NAD+ is also important for the production of the happiness hormone dopamine. Thus, low NAD+ levels not only inhibit energy production in the brain, but also upset the natural balance of dopamine levels. This causes the affected person to seek "dopamine spikes" on the basis of stimulation. 8 craving for ecstasy and natural highs: A positive approach to mood alteration.
It could be gallons of coffee, sugar or even facebook. A vicious cycle begins as these things further confound dopamine levels.
For this reason, if you are deficient in NAD+, you should avoid these "kicks" and permanently rebalance your neurotransmitters.
2. NAD+ optimizes metabolism and thus fat burning
We have already learned that NAD+ activates sirtuins that improve fat burning, mitochondrial function and energy production.
NAD+, like the thyroid hormone T3, has a significant impact on metabolism. Low levels of NAD+ and T3 cause depression and low thermogenesis: we, especially hands and feet, start to freeze. 9 effect of coenzymes and thyroid hormones on the dual activities of xenopus cytosolic thyroid-hormone-binding protein (xctbp) with aldehyde dehydrogenase activity.
3. NAD+ supports the immune system and reduces chronic inflammation
Chronic infections and inflammation are a common cause of disease and reduced performance. Of course, a permanent change to a healthy diet, sufficient exercise and a balanced lifestyle are basic prerequisites for treating such chronic diseases at their origin.
But also a correction of the NAD+ level is a possible way.
Animal studies have shown that increasing NAD+ levels can reverse autoimmune diseases. If NAD+ levels in the body can be restored, the development of autoimmune diseases can even be prevented, as the immune system is programmed by NAD+ to protect rather than attack. 10 new discovery in regulating autoimmune diseases.
4. NAD+ activates important enzymes
These include, for example, the sirtuins, which I have already mentioned. Especially sirt1 and sirt3 have strong effects on the body: 11 SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM. 12 targeting sirtuin 1 to improve metabolism: all you need is NAD+?
These sirtuins activate a cascade of genes responsible for the following functions, among others:
- Increase mitochondria
- Increased fatty acid oxidation
- Inhibition from new adipose tissue
- Tumor suppressor (cells with DNA damage do not continue to form).)
- Increased insulin sensitivity
- Optimization of the circadian rhythm (optimized bio-rhythm)
- Increase of important antioxidants in the cell
NAD+ also activates the enzyme PARP, which repairs damaged genetic material, i.e. DNA. People who grow particularly old have a higher activity of this enzyme. 13 NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival.
Here’s how to naturally increase your NAD+ levels
The classic suspects that optimize your mitochondria will also increase your NAD+ levels. Read more in the article Strengthening mitochondria: cell training for more energy.
Production and important precursors of NAD+
The body has 2 different ways of producing NAD+.
- "de novo." NAD+ is newly produced from the building blocks tryptophan, nicotinic acid (vitamin B3) and nicotinamide.
- "salvage pathway: a kind of recycling in which NAD+ is produced from already larger molecules. This process is significantly more energy efficient than "de novo" synthesis.
To support the salvage pathway, nicotinamide riboside or nicotinamide mononucleotide can be supplemented particularly effectively.
Here are 7 tips on how to increase your NAD+ production.
1. Endurance sports and iron lifting
It is only logical that during periods of high energy demand, the cell makes a lot of NAD+ to produce energy.
We recommend aerobic training, HIT training and HIIT training for this purpose. Aerobic and light exercise is an excellent way to incorporate it into your morning routine and wake up your body without causing too much immediate stress.
Important: especially if you are on a ketogenic diet, your main focus should be on aerobic exercise. If you are doing glycolytic training such as crossfit, iron lifting or HIT training, we recommend high quality carbohydrates such as. From root vegetables, to take to you.
2. Therapeutic ketosis
The metabolic state of ketosis, in addition to the increase of mitochondria, increases the level of NAD+. Especially people who want to increase their energy level and who have to concentrate for long periods in their professional life benefit from a ketogenic diet.
If you want to know how to get into the physiologically valuable state of ketosis as quickly as possible, you should read this article: ketosis – healthier, leaner, more efficient?
3. Fasting and calorie restriction increase your NAD+ levels
Your body is a perfectly tuned system that houses extremely intelligent information systems and is as finely tuned as a Swiss watch.
NAD+ is a good example of this information structure. if your body has relatively low NAD+ levels, this is a sign that either too many calories are being consumed, too little energy is being used through exercise, for example, or there is too little oxygen in the cells.
If instead you have high NAD+ levels, it is a sign that an extreme amount of energy is being used and more calories are being burned than consumed.
This is why physical exercise, fasting or caloric restriction lead to high NAD+ levels. The important thing here is to find a balance.
The body and physiology function through opposites that are balanced. Catabolic-anabolic, exercise-rest – two sides are always needed.
4. Hyperthermic stimuli like sauna, infrared light or hot baths
For me it has become a ritual. After bouldering, it’s off to the sauna. It not only has a relaxing effect on the mind, but also improves regeneration and detoxifies the body. The hyperthermic stimulus causes the NAD+ level to rise. 14 SIRT1 regulation of the heat shock response in an HSF1-dependent manner and the impact of caloric restriction.
Saunas are also considered a panacea and are part of every historical culture. The noticeable effect comes not only from sweating out toxins, but also from the fact that saunas increase NAD+.
You can achieve this not only with the classic Finnish sauna. You will experience the same effect in steam saunas or hot baths.
Infrared saunas (and infrared light in general) are becoming more and more popular, as they also have a deep tissue coatings reach.
since infrared also increases SIRT1, infrared saunas are ideal for boosting mitochondrial performance. 15 effect of near-infrared light exposure on mitochondrial signaling in C2C12 muscle cells.
I personally have my head irradiated with infrared light in the morning to wake up faster and increase the energy production in my brain.
5. Fermented foods
This is an incredibly interesting point. Fermented foods are not only a blessing for your intestinal flora. They contain many B vitamins, beneficial organic acids, and NAD+. This is due to the fact that during the formation of lactic acid (especially lactate) by NADH, NAD+ is formed. 16 the effect of increasing NADH availability on the redistribution of metabolic fluxes in escherichia coli chemostat cultures.
How can you use this for your purposes? We recommend the regular consumption of fermented foods such as kimchi, sauerkraut or kombucha.
6. Kombucha as a healthy lemonade
I am a huge fan of kombucha, a fermented tea beverage that contains many health-promoting substances such as helpful acids, vitamins, minerals, probiotics and NAD+. I allow myself a glass a day now and then, while others swear by this drink and consume several glasses a day of it.
Important: it must be unpasteurized kombucha, otherwise the useful properties are lost and the drink is no better than lemonade. You can even make kombucha yourself with a little practice.
7. Food supplements and nutrients
- Nicotinamide riboside
- Malic acid 17malate and fumarate extend lifespan in caenorhabditis elegans.
- Resveratrol 18resveratrol increases intracellular NAD+ levels through up regulation of the NAD+ synthetic enzyme nicotinamide mononucleotide adenylyltransferase.
- Apigenin 19flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.
- Leucine 20leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice.
These factors inhibit your NAD+ values
there are several lifestyle factors and chronic health problems that can mess up your NAD+ values. So that you are not a victim of your habits, here is a list of the biggest influencers.
1. A bad biorhythm
What happens when the gears of the human clockwork are no longer in tune with each other?? Compensation mechanisms start to work. The performance decreases rapidly and eventually the body becomes ill.
The circadian rhythm, for example, has a great influence on the secretion of the NAMPT enzyme, which ultimately leads to the production of NAD+. If there is not enough NAMPT, less NAD+ is produced. Logical.
So if you think that a healthy diet is enough to stay healthy and productive or to be "in the zone" every day, i’m sorry to disappoint you.
If you completely disrupt your biorhythm, for example by exposing yourself to too much artificial light in the evening or by disrupting the communication of your cells through electromagnetic radiation, this can have fatal consequences.
Tip: switch your electronic devices to flight mode for the night so your body gets a break from electromagnetic radiation. Or even better, sleep in a room without any electronic devices. (the argument that you need your cell phone alarm clock does not count). there are so many cheap analog alarm clocks.)
2. Chronic inflammation
Chronic inflammation is a typical performance killer. They hide in the body and often manifest themselves through symptoms such as fatigue, problems concentrating and poorer recovery.
However, you also prevent the production of sufficient NAD+.
It is important that you find the trigger of these chronic inflammations. Are they hidden food intolerances, intestinal problems (leaky gut), too much stress, or sleep disorders?
3. Gluttony and immoderation
In the catholic church, gluttony is one of the seven deadly sins. Even though I am not a follower of the catholic church, this deadly sin is actually very useful. At least if we talk about health and NAD+ values.
an oversupply of calories, high blood glucose levels and permanent high insulin lead to inhibition of NAD+ and SIRT1. We don’t really want to have either. Therefore: eat slowly, consciously and in moderation.
4. Alcohol
While we are on the subject of "gluttony. Alcohol in moderation and for enjoyment is perfectly okay. (as long as you do not suffer from chronic illnesses that are immediately aggravated by the consumption of alcohol.)
However, alcohol also lowers your NAD+ levels, which may explain some of the negative effects of alcohol. 21 the effect of alcohol stress on nicotinamide adenine dinucleotide (NAD+) levels in drosophila.
But what happens when you increase your NAD+ values in a deficient?
This question cannot be answered in a general way, because it always depends on which means you use to increase your NAD+ level. Is it the same as an infusion? Using supplements like nicotinamide riboside? Or adapt your lifestyle?
Especially for people who feel low and lacking in energy, a lifestyle adjustment at the beginning can actually mean a worsening of symptoms.
Do not overburden your body
If you suffer from chronic inflammation or illness and suddenly find yourself on a ketogenic diet, intermittent fasting and incorporating high-intensity training into your daily routine, your cortisol levels will shoot up like the space X rocket.
This means: integrate the lifestyle changes into your everyday life only gradually and listen to your body.
Conclusion: NAD+ is a super molecule that is replicable through targeted biohacking
This article had it in itself, or? I hope you were able to take away some things for yourself.
In principle, it’s always the same: not eating too much, intermittent fasting, low sugar and other complex carbohydrates, lots of exercise and enough sleep are basics that optimize so much more beyond the NAD+ level. The best way to get more out of yourself is to start rethinking your lifestyle right away.